During the preparation for a two year overseas business trip in Nigeria, an American manager in the 70`s had to be inoculated against the great number (more than thirty) of diseases from the jungle and hay fever to hepatitis. But all these vaccination couldn't guarantee the safety and absolute protection from the hazards of the overseas sicknesses. Always there is a chance to become infected with an unknown malady. In the end of the twenty`s century the dangerous overseas diseases were the main culture shock for the foreign businessmen. What is the culture shock in the present-day business sector? Why the managers from the other country feel themselves uneasy and uncomfortable? What should be done to avoid the cultural shock abroad? With the development of the international business and with the expansion of the globalization process the majority of the huge enterprisers and corporations are obliges to work abroad. The overwhelming number of such companies began with the exporting operations. In the present day the companies became bigger and work in the overseas countries more and more. While the export operations need only infrequent short business trips abroad, the other international business activities require long-term trips of the managers outside the home country. These overseas trips have different objectives from the invasion of technologies to the control and supervision. The fact is that the common and usual business behavior in the home country may be abusive and indecent in overseas country. Even if the external traditions and customs are similar and universal, there are a lot of different individual features in every culture. And this different concepts can play a great pole and exert the substantial influence on the international management of business corporations. All these conditions determinate the necessity of the serious preparation for the international business trip and the support of the managers abroad.