Kansas City is sometimes referred to as the Heart of America because it is within 250 miles of the geographic and population centers of the United States. Most of Kansas City, Missouri's real estate is located in Jackson, Clay, Platte, and Cass counties. It is the most populous city in Missouri, the seventh largest city in the Midwest, and the 40th most populous city in America. As of 2005, the city had an estimated population of 444,965. You might consider this as a point of relocation and think about moving to Kansas City or purchasing real estate.